KRAS.HR - Kras

1. KRAS mutation: from undruggable to druggable in cancer

nature.com - Web Nov 15, 2021  · Introduction to KRAS. The KRAS gene is a member of the rat sarcoma viral oncogene family (RAS), which includes two other isoforms in humans: the Harvey and …

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2. KRAS gene: MedlinePlus Genetics

medlineplus.gov - Web The KRAS gene provides instructions for making a protein called K-Ras that is part of a signaling pathway known as the RAS/MAPK pathway. The protein relays signals from …

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3. KRAS: From undruggable to a druggable Cancer Target

nih.gov - Web Various attempts to inhibit Kras in the past were unsuccessful. Recently, several small molecules (AMG510, MRTX849, JNJ-74699157, and LY3499446) have been developed …

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4. KRAS - an overview | ScienceDirect Topics

sciencedirect.com - Web KRAS Mutations Reprogram Glutamine and Glucose Metabolism. KRAS is an oncogene that is mutated in ~ 90% of pancreatic cancers and less commonly mutated in cancer …

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5. KRAS Biomarker | Colorectal Cancer Alliance

ccalliance.org - Web The KRAS gene is an oncogene because when it is mutated or changed it can cause normal cells to become cancerous. KRAS is a member of the RAS family of genes that …

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6. KRAS and Lung Cancer | American Lung Association

lung.org - Web Nov 17, 2022  · It is called KRAS because it was first identified as causing cancer in Kirsten RAt Sarcoma virus. Normally KRAS serves as an information hub for signals in the cell …

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7. Targeting KRAS: The Elephant in the Room of Epithelial Cancers

frontiersin.org - Web Mar 11, 2021  · Mutations of the proto-oncogene KRAS are the most frequent gain-of-function alterations found in cancer. KRAS is mutated in about 30% of all human tumors, …

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8. KRAS G12C Inhibition with Sotorasib in Advanced Solid Tumors

nejm.org - Web Sep 20, 2020  · Sotorasib showed encouraging anticancer activity in patients with heavily pretreated advanced solid tumors harboring the KRAS p.G12C mutation. Grade 3 or 4 …

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9. KRAS Gene - GeneCards | RASK Protein | RASK Antibody

genecards.org - Web Aug 2, 2023  · NCBI Gene Summary for KRAS Gene. This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the …

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10. MRTX1133 Targets Tumors with KRAS G12D Mutations - NCI

cancer.gov - Web Jan 12, 2023  · Indeed, Dr. Stanger’s team found that blocking KRAS G12D activity with MRTX1133 resulted in several changes in the tumor microenvironment. Most notably, he …

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11. Understanding the Absence of KRAS As an Indirect Biomarker of ...

ascopubs.org - Web Sep 28, 2023  · Dr. Bennett Caughey. Key Points: Patients with KRAS wild-type (WT) pancreatic ductal adenocarcinoma (PDAC) are a relatively rare population; often they …

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12. Kura: Preclinical Data Shows Potential Of KO-2806 To Enhance …

businessinsider.com - Web 1 day ago · Kura: Preclinical Data Shows Potential Of KO-2806 To Enhance Antitumor Activity Of KRAS Inhibitors . RTTNews. Sep. 28, 2023, 08:56 AM

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13. KRAS DepMap Gene Summary

depmap.org - Web By using this site, you agree to our Terms and Conditions Got it!

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14. Kura Oncology Reports Preclinical Data Showing Ability of

globenewswire.com - Web 1 day ago  · The Company’s new preclinical data show that co-treatment of preclinical models of KRAS G12C -mutant NSCLC with KO-2806 and adagrasib deepens signaling …

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15. 王作云/梁春敏团队发现K-RAS突变诱发肺腺癌的新机制

fudan.edu.cn - Web Sep 25, 2023  · 在该研究中，通过 LSL-Kras G12D 激活诱导肺腺癌小鼠模型，发现 CBX4 缺失的 LSL-Kras G12D 突变小鼠中肺腺癌发生多，发展快，且预后更差。然而在体外细 …

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16. District attorney asked to investigate misappropriation of Gray …

sunjournal.com - Web Sep 25, 2023  · Shawn Patrick Ouellette/Staff Photographer. The Cumberland County District Attorney’s office was asked to investigate misappropriated town funds in Gray, …

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